Here is one thing we can be sure about Nick he will lose Adalind at the least, but also Kelly. Nicks entire story line is about lose. The price of being a Grimm. Ever Season it is always the one closet to him. With Adalind now leaving It is jest setting up for the lost. Where they are going with Eve. Where Adalind does thing to make herself a victim. Juliette has always had her efforts make her the victim. After becoming a hexenbiest. Hexenette started making herself a victim. Now you have Eve who is nobodies victim. Though her perspective has changed, she has always had a tragic ending. Coma, Nick a Zombie, Adlind sleeping with Nick, then being shot after becoming a hexenbiest. Eve has now been running around playing super spy. She is not being victimized, tormented, or sent on an emotional roller coaster. All things from previous seasons. The question do they stick to the tragic out come. or do they break the pattern. If they break it for Eve will they break it for Nick. Will this be the one time he does suffer loss. Will he actually win this time. If that is true might they even let Adalind win and not be a victim. Is that what the writers meant by a new show. I am sure there would be a lot of fans that would cheer a happy ending. Considering none of the cast has even eluded to a dark ending, only it is an exciting ending. Completely changing the predicted outcome may be what is coming.
Embrace your inner Biest..... We all have one